osmotic diuretics การใช้

• Glucose, like mannitol, is a sugar that can behave as an osmotic diuretic.
• In the nephron, osmotic diuretics act at the portions of the nephron that are water-permeable.
• Osmotic diuretics works by expanding extracellular fluid and plasma volume, therefore increasing blood flow to the kidney.
• Osmotic diuretics have their major effect in the proximal convoluted tubule and the descending limb of Henle's loop.
• Impaction often leads to constipation and malnutrition, and possibly death unless treated promptly with laxatives such as the osmotic diuretic lactulose.
• In such occasions, mannitol ( osmotic diuretic ) or hypertonic saline are given to draw fluid out of the oedematus cerebrum to minimise secondary injury.
• It was previously believed that the primary mechanism of osmotic diuretics such as mannitol is that they are filtered in the glomerulus, but cannot be reabsorbed.